Are all members of a genetic tumor family bound to develop tumors?

Are all members of a genetic tumor family bound to develop tumors?

Are all members of a genetic tumor family bound to develop tumors? The answer is no.

Hereditary tumor families pass the disease-causing mutation gene to multiple members of the family through heredity, resulting in a significant increase in the risk of certain or more tumors in the members carrying the disease-causing mutation gene, that is, an increase in the susceptibility to cancer.

For example, BRCA1 mutation carriers in hereditary breast/ovarian cancer families have a 44% lifetime risk of developing ovarian cancer by age 80, and BRCA2 mutation carriers have a 17% lifetime risk of developing ovarian cancer by age 80.

Therefore, women with this gene mutation do not necessarily develop ovarian cancer, but have a higher risk than the normal population.

Genetically related gynecological tumors often present autosomal dominant inheritance characteristics, so the general rule is that if one of the parents carries the disease-causing gene, the probability of disease in their children is about 50%, and the genetic gender is unrelated, there is no difference in the probability of male and female morbidity, and it will exist in successive generations.

Tag: Hereditary tumors